Oxidative modification and aggregation of creatine kinase from aged mouse skeletal muscle

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Oxidative modification and aggregation of creatine kinase from aged mouse skeletal muscle

Creatine kinase catalyzes the reversible transfer of the gamma phosphate from ATP to creatine forming the high energy compound creatine phosphate. Muscle creatine kinase (CKm) activity maintains energetic homeostasis as variations in energy requirements dictate that ATP be readily available. Recent studies suggest that CKm activity is altered during aging. Proteomic analyses have shown that CKm...

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Oxidative system in aged skeletal muscle.

Aging is an inevitable biological process that is characterized by a general decline in the physiological and biochemical functions of the major systems. In the case of the neuromuscular system, reductions in strength and mobility cause a deterioration in motor performance, impaired mobility and disability. At the cellular level, aging is caused by a progressive decline in mitochondrial functio...

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ژورنال

عنوان ژورنال: Aging

سال: 2009

ISSN: 1945-4589

DOI: 10.18632/aging.100055